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inducible nitric oxide synthase


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'inducible nitric oxide synthase' can also refer to...

inducible nitric oxide synthase

inducible nitric oxide synthase

Inducible nitric oxide synthase and vascular injury

Inducible nitric oxide synthase and cardiovascular disease

Nitric oxide production and inducible nitric oxide synthase expression induced by Prevotella nigrescens lipopolysaccharide

Pneumococci Stimulate the Production of the Inducible Nitric Oxide Synthase and Nitric Oxide by Murine Macrophages

Inducible nitric oxide synthase and development of new migraine treatments

Inducible nitric oxide synthase increases secretion from inflamed salivary glands

The role of inducible nitric oxide synthase in cardiac allograft rejection

Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque

Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis

Induction of inducible nitric oxide synthase expression in human secretory endometrium.

Regulation of inducible nitric oxide synthase in post-operative adhesions

Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques

Involvement of inducible nitric oxide synthase in radiation-induced vascular endothelial damage

Intestinal ischemia induces late preconditioning against myocardial infarction: a role for inducible nitric oxide synthase

Tumor necrosis factor-α induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes

Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma

Inducible Nitric Oxide Synthase (iNOS) and Nitric Oxide (NO) are Important Mediators of Reflux-induced Cell Signalling in Esophageal Cells

 

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(iNOS)

An enzyme, found in activated macrophages and certain other tissues, that catalyses the production of the highly reactive molecule nitric oxide (NO). Macrophages that have ingested bacteria or other pathogens are prompted by helper T cells (TH1 cells) to destroy those pathogens. γ-Interferon (IFN-γ) secreted by the TH1 cell, in combination with tumour necrosis factor α (TNF-α) from the activated macrophage, causes increased expression of the iNOS gene, and hence synthesis of the enzyme, leading to production of NO. This has broad antimicrobial activity: it can be both used inside phagocytic vesicles within the macrophage and released outside the cell, for example to attack large pathogens, such as parasitic worms. Expression of iNOS also occurs more widely during inflammation and wound healing.

Subjects: Biological Sciences.


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