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Indy


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A gene in Drosophila that has a profound effect upon life span. The gene symbol is an acronym for I'm not dead yet. The gene encodes a protein, localized in the plasma membranes of cells of the fat body (q.v.), that transports molecules generated during the citric acid cycle (q.v.). Flies with two normal alleles have a mean life span of 37 days. Flies heterozygous for Indy mutants have a mean life span of 70 days. Indy homozygotes show only a 15% increase in life span. See heterozygote advantage.

Subjects: Genetics and Genomics.


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