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Transfer ribonucleic acid (t-RNA), that in eukaryotes carries methionine and in prokaryotes N-formylmethionine, which binds to the small unit of a ribosome bearing messenger ribonucleic acid (m-RNA), thus forming an initiation complex. This, in the presence of three protein initiation factors and GTP which is hydrolysed, enables the large ribosomal subunit to associate with the complex, and peptide-chain synthesis to proceed.

Subjects: Biological Sciences.

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