A nucleoside formed from hypoxanthine attached to a ribose ring. Commonly found in tRNAs; essential for proper translation of the genetic code because it fails to form specific pair bonds with the other bases. This allows matching of a single tRNA to several codons (see wobble hypothesis). Primers for PCR that contain inosine will tolerate some mismatch, which is useful when trying to clone homologous protein by using degenerate primers. Inosine pranobex (TN Imunovir, Isoprinosine, Inosiplex) is an antiviral drug used to treat herpes simplex.
Subjects: Medicine and Health — Chemistry.