A family of compounds (IPGs) released by heterotrimeric G-protein-regulated hydrolysis of membrane-bound glycosylphosphatidylinositols. They are thought to be second messengers of insulin. There are two subfamilies, IPG-A and IPG-P; IPG-A inhibits PKA from bovine heart, decreases phosphoenolypyruvate carboxykinase mRNA levels in rat hepatoma cells, stimulates lipogenesis, and inhibits leptin release in rat adipocytes. IPG-P stimulates bovine heart pyruvate dehydrogenase phosphatase, and abnormal secretion may occur in pre-elampsia.
Subjects: Medicine and Health.