Any of certain polypeptides (see growth factor) that are structurally similar to the hormone insulin and promote division and growth of cells. There are two principal types: IGF-I ( somatomedin C) and IGF-II ( somatomedin A). Growth hormone stimulates the liver to release IGF-I, which circulates in the bloodstream bound to several specific IGF-binding proteins. IGF-I is also produced locally in various tissues, including kidney, muscle, bone, and the gastrointestinal tract.
Subjects: Chemistry — Medicine and Health.