integrin cytoplasmic domain-associated protein-1

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A protein (alternatively spliced isoforms ICAP1α, 200 aa; ICAP1β, 150 aa) that interacts with the conserved NPXY (Asn-Pro-X-Tyr) sequence motif found in the C-terminal region of β1-*integrin. It interacts with KRIT1 in regulating vascular morphogenesis. The activity of ICAP1 is regulated by calcium/calmodulin-dependent protein kinase II (CAMK2).

Subjects: Medicine and Health.

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