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A plasma serine peptidase inhibitor (inter-α-(trypsin) inhibitor, ~180 kDa) composed of bikunin in association with one of a set of similar heavy chains (H1, 2, etc., 900–950 aa) encoded by separate genes (ITH1–3). The product of a fourth gene (ITIH4) has sequence similarities and a polymorphism in this gene is associated with susceptibility to hypercholesterolaemia.

Subjects: Medicine and Health.

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