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A heterodimeric cytokine (NK stimulatory factor; cytotoxic lymphocyte maturation factor, IL12/p70, 219 aa and 328 aa) that promotes Th1 responses and regulates immunoglobulin isotype selection. The heterodimeric receptor (662 and 862 aa) activates the JAK–STAT pathway. High levels have been implicated in autoimmune disorders.

Subjects: Chemistry.

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