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A cytokine (lymphocyte chemoattractant factor, LCF) produced mainly, but not exclusively, by CD8+ T cells that is a chemoattractant for cells with cell-surface CD4. The IL-16 protein (121 aa) is derived from a much larger biologically inactive precursor (1332 aa) by caspase-3 cleavage. May bind to CC-CKR-5 and contribute to the blocking of HIV internalization.

Subjects: Medicine and Health.

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