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interleukin 2


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(IL-2)

An immunoregulatory cytokine (T-cell growth factor, TCGF; thymocyte stimulating factor, TSF), produced by activated T cells, that causes activation of other T cells independently of the antigen. The receptor (IL2R) has unique α (CD25, 272 aa; sometimes IL2RA, where ‘RA’ is not to be confused with ‘ra’ in IL1ra) and β (CD122, 551 aa) subunits and a common γ chain (369 aa) shared by all receptors for the IL-2 family of cytokines (IL-4, IL-7, IL-9, IL-15, and IL-21). A recombinant form of IL-2 (Proleukin™) has been approved for the treatment of some tumours.

Subjects: Medicine and Health — Chemistry.


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