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interleukin 8


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(IL-8)

A cytokine of the CXC family (neutrophil activating protein, NAP-1, CXCL8, 72 aa), first isolated as a chemokine, a potent chemotactic and chemokinetic factor for neutrophils and basophils. The 99 aa precursor is processed by cathepsin L to produce the active form. The receptor (CXCR1) is a dimeric G-protein-coupled glycoprotein with 350 aa (CD181) and 360 aa (CD182) subunits.

Subjects: Medicine and Health — Chemistry.


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