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A pro-inflammatory cytokine (interferon-γ inducing factor, IGIF, IIF) of the IL-1 family, that induces interferon-γ production from T cells, augments T-cell proliferation and NK activity in cultures of human peripheral blood mononuclear cells, and has a role in angiogenesis. The precursor is processed by caspase-1 to produce the mature protein (157 aa). The receptor (541 aa) activates NFκB.

Subjects: Medicine and Health.

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