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A cytokine of the IL-10 family (IL-10-related T-cell-derived inducible factor, IL-TIF, 179 aa), produced by activated T cells. Binding to the receptor, which shares a common subunit with the IL-10 receptor, activates the STAT pathway. It has been suggested that IL-22, together with IL-17, mediates crosstalk between the immune system and epithelial cells and is involved in host defence against extracellular pathogens at mucosal sites.

Subjects: Medicine and Health.

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