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A heterodimeric cytokine composed of one IL-12 subunit (p40) and a different subunit, p19 (189 aa). It is pro-inflammatory, involved in the recruitment of inflammatory cells in Th1-mediated diseases, and may play a role in immune-mediated demyelination of the peripheral nerves in Landry–Guillain–Barré syndrome. The receptor (629 aa) is distinct from that for IL-12 and probably activates the JAK–STAT signalling pathway.

Subjects: Medicine and Health.

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