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A cytokine (nuclear factor from high endothelial venules, NFHEV, 270 aa) constitutively expressed by smooth muscle cells and bronchial epithelial cells. Expression in primary lung or dermal fibroblasts and keratinocytes is induced by treatment with TNFα and IL-1β. The receptor is IL-1 receptor-like-1 (ST2, 556 aa), activates NFκB and MAP kinases, and leads to expression of IL-4, IL-5, and IL-13.

Subjects: Medicine and Health.

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