interleukin-6 cytokine family

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Cytokines that all act through receptors with a common gp130 signalling subunit. Members include interleukin-6, interleukin-11, ciliary neurotrophic factor, LIF, oncostatin M, and cardiotrophin-1. Degradation of gp 130 is regulated through a phosphorylation–dephosphorylation mechanism in which protein phosphatase-2A is crucially involved; gp 130 is a potential therapeutic target in cancers.

Subjects: Medicine and Health.

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