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Multidomain adaptor (scaffold) proteins involved in clathrin-mediated endocytosis, regulation of actin polymerization, and Ras/MAPK signalling. Intersectin-1 (ITSN-1) is required for fission of caveolae and their internalization in endothelial cells and has also been reported to be an antiapoptotic protein. Through its dynamin binding it is involved in synapse formation and endocytosis in the nervous system.

Subjects: Medicine and Health.

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