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Multidomain scaffold proteins (IQ motif-containing GTPase activating proteins, p195, IQGAP1, 1657 aa; IQGAP2, 1575 aa) that bind to a wide variety of targets, including actin, catenin, rho family GTPases, and calmodulin (through the IQ motif) and that modulate cell–cell adhesion, transcription, cytoskeletal architecture, and signalling pathways.

Subjects: Medicine and Health.

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