islet cell autoantigen

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An autoantigen (ICA69, 69kDa, 483 aa) associated with type 1 diabetes. It binds to the small GTPase rab2 and has an extended BAR domain that interacts with membrane phospholipids. ICA69 is enriched in the Golgi complex and probably has a role in regulating secretory granule transport.

http://www.endocytosis.org/BARdomains/BARs.html Additional information about BAR domains.

Subjects: Medicine and Health.

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