isotope dilution

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'isotope dilution' can also refer to...

isotope dilution

isotope dilution

isotope dilution

isotopic dilution analysis

isotope dilution analysis

isotope dilution analysis

isotopic dilution analysis

isotopic dilution analysis

Isotope Dilution-Mass Spectrometry Determination of Blood Cyanide by Headspace Gas Chromatography

Quantification of Saxitoxin and Neosaxitoxin in Human Urine Utilizing Isotope Dilution Tandem Mass Spectrometry

Exposure Assessment of Airborne Acrylamide for Occupationally Exposed Workers by Using an Isotope-Dilution Gas Chromatography Coupled with Mass Spectrometry

Determination of γ-Aminobutyric Acid in Food Matrices by Isotope Dilution Hydrophilic Interaction Chromatography Coupled to Mass Spectrometry

Photosynthetic rates in the surface waters of the Red Sea: the radiocarbon versus the non-isotopic dilution method

Simultaneous Determination of Thiophanate-Methyl and Its Metabolite Carbendazim in Tea Using Isotope Dilution Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry

Simultaneous Measurement of 3-Chlorotyrosine and 3,5-Dichlorotyrosine in Whole Blood, Serum and Plasma by Isotope Dilution HPLC–MS-MS

Quantitation of Organophosphorus Nerve Agent Metabolites in Human Urine Using Isotope Dilution Gas Chromatography-Tandem Mass Spectrometry

An Enhanced Throughput Method for Quantification of Sulfur Mustard Adducts to Human Serum Albumin Via Isotope Dilution Tandem Mass Spectrometry

Simultaneous Determination of 11 β-Agonists in Human Urine Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Isotope Dilution

Correlations Between Phthalate Metabolites in Urine, Serum, and Seminal Plasma from Young Danish Men Determined by Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry


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An analytical technique used to determine the concentration of an element in a sample by means of a mass spectrometer. The method is based on the determination of the isotopic composition of the element in a mixture. A known quantity of a compound containing an unknown quantity of a particular element is mixed with a spike (a known weight of a radioactive isotope of the element). The specific activity (disintegrations per second per kilogram) of the spike is known precisely, so the isotopic composition of the mixture can be used to calculate the amount of the element in the sample. A small amount of the mixture is isolated from the sample, weighed, and its specific activity measured. The concentration of the inactive element in the sample may be estimated by the dilution of the radiotracer. Isotope dilution analysis can be applied to all elements that have two or more naturally occurring isotopes (about 80% of all elements), provided that a spike enriched in one of the isotopes of that element is available. As a technique it has several advantages over other analytical methods. It is free of interference from other elements present and its accuracy is governed by the calibration of the spike solution.

Subjects: Earth Sciences and Geography.

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