Overview

JAB


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1. Jun activation domain-binding protein-1 (JAB1), the fifth subunit (37 kDa) of the [COP9 signalosome], that selectively potentiates transactivation by Jun or JunD but not JunB. It interacts with the cytoplasmic domain of the β2 subunit of the αLβ2 integrin, LFA-1, thus linking adhesion proteins with transcriptional regulation.

2. JAK-binding protein. See SOCS.

Subjects: Medicine and Health.


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