A family of transmembrane molecules with extracellular immunoglobulin domains, involved in epithelial junctions (junctional adhesion molecules). JAM-1 (JAM-A, 299 aa) plays a role in regulating epithelial tight junctions, is a ligand of the integrin, LFA-1, and is a reovirus receptor. It is also found on blood leucocytes and platelets. JAM-2 (JAM-B, vascular endothelial JAM, VEJAM) is important in endothelial integrity and interacts with T cells but not other leucocytes. JAM-3 (JAM-C) is a counter-receptor for the leucocyte integrin Mac-1 and promotes neutrophil transendothelial migration in vitro and in vivo.
Subjects: Medicine and Health.