Overview

Janus kinase


'Janus kinase' can also refer to...

Janus kinase

Janus kinase

Janus kinase

Janus kinase

Janus kinase 2

Janus kinase 2

Janus kinase 2

Janus kinase 3: the controller and the controlled

Janus Kinase 2: An Epigenetic ‘Writer’ that Activates Leukemogenic Genes

Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens

P014. Selective Janus Kinase 1 inhibitor targets monocytes and tissue macrophages during DSS colitis

15PAssessment of Janus kinase family and Src family kinase signalling pathway involvement in epidermal growth factor-induced epithelial-mesenchymal transition in MDA-MB-468 breast cancer cells

Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7

P122Cardiac-specific deletion of Janus kinase 2 (JAK2) reveals marked cardiac pathology indicative of hypertrophy, heart failure and sudden cardiac death

P069. TD-1473, a novel, potent, and orally administered, GI-targeted, pan-Janus kinase (JAK) inhibitor

P014. Tofacitinib and a selective Janus kinase 1 inhibitor are equally potent in suppressing human macrophage function and T-cell proliferation

P020. The efficacy of tofacitinib and a selective Janus kinase 1 inhibitor in dextran sulphate sodium colitis models

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes

 

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(JAK)

Any of a family of receptor-associated tyrosine kinases that play a crucial role in many intracellular signalling pathways, particularly ones involving cytokines. Binding of ligand to the associated receptors brings two JAKs together, enabling them to activate each other and phosphorylate tyrosine residues in the intracellular regions of the receptors. This recruits cytosolic proteins called STATs (signal transducers and activators of transcription), which are phosphorylated by the JAKs, associate in pairs (dimerize), and migrate to the nucleus, where they bind to various gene control sites to alter levels of gene transcription. The name ‘Janus’ reflects the symmetrical arrangement of the kinase domains in the paired JAK proteins, after the Roman god and gatekeeper of heaven who had two faces, one in front and one behind.

Subjects: Chemistry — Biological Sciences.


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