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jasplakinolide


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A cyclic peptide (~710 Da) isolated from the marine sponge Jaspis johnstoni. Stabilizes F-actin in vitro and binds to the same or similar site as phalloidin, but permeates into cells more readily. In vivo, may disrupt the cytoskeletal microfilament meshwork by inducing formation of amorphous actin polymers.

Subjects: Medicine and Health.


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