JH domains

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Domains (JAK homology domains) found in JAKs. JH1 is the the catalytic protein tyrosine kinase domain, the JH2 domain is a catalytically inactive pseudokinase that inhibits basal Jak activity. JH1 and JH3 domains of Jak2 bind directly to protein tyrosine phosphatase-2A.

Subjects: Medicine and Health.

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