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junctin


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One of three proteins encoded by the ASPH gene (the others being ASPH and junctate (humbug). Aspartate β-hydroxylase (ASPH, 744 aa) catalyses the post-translational hydroxylation of aspartic acid or asparagine residues within epidermal growth factor-like domains of numerous proteins. Junctin (225 aa) is a transmembrane calsequestrin-binding protein found in junctional sarcoplasmic reticulum from cardiac and striated muscle tissue colocalized with the ryanodine receptor and triadin. Junctate (299 aa) shares the first 93 aa of the long isoform of junctin but has a much wider tissue distribution; it binds calcium with high capacity and moderate affinity.

Subjects: Medicine and Health.


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