A glycosaminoglycan in which the repeating disaccharide is galactose β1–4 linked to N-acetylglucosamine that is sulphated at C-6 of either or both of the Gal or GlcNAc monosaccharides. The polysaccharide chain is linked to various core proteins including lumican, keratocan, mimecan, fibromodulin, proline arginine-rich end leucine-rich repeat protein (PRELP), osteoadherin, and aggrecan. Keratan sulphate I (KSI) is N-linked to asparagine residues via N-acetylglucosamine and KSII is O-linked to specific serine or threonine residues via N-acetylgalactosamine. Both are found in a range of tissues although originally KSI was thought to be specific to cornea.
Subjects: Chemistry — Medicine and Health.