KH domain

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KH domain

KH domain

KH domain: one motif, two folds

Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain

Structure and RNA binding of the third KH domain of poly(C)-binding protein 1

KH domains with impaired nucleic acid binding as a tool for functional analysis

Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160

Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress

Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana

Arabidopsis thaliana exosome subunit AtRrp4p is a hydrolytic 3′→5′ exonuclease containing S1 and KH RNA-binding domains

Scp160p, a multiple KH-domain protein, is a component of mRNP complexes in yeast

The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins

A KH Domain-Containing Putative RNA-Binding Protein Is Critical for Heat Stress-Responsive Gene Regulation and Thermotolerance in Arabidopsis

Isolation and expression of a novel starch‐storing cell‐specific gene containing the KH RNA binding domain from tobacco‐cultured cells BY‐2

RNAi‐mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non‐dividing human cells but does not initially inhibit protein synthesis

Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution


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An evolutionarily conserved sequence (K homology domain, ~70 aa) present in a variety of nucleic acid-binding proteins. The KH domain binds RNA in a sequence-specific fashion and may be present in multiple copies.

Subjects: Chemistry.

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