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kexin


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kexins

kexin

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review

Gene Cloning, Expression, and Immunological Characterization of Kexin in Rat Pneumocystis carinii

Genomic Organization and Alternative Splicing of Human PACE4 (SPC4), Kexin-Like Processing Endoprotease

PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9

Analysis of genes to predict the effects of proprotein convertase subtilisin/kexin type 9-inhibitors and statins

Expression of a kexin-like gene from the human pathogenic fungus Paracoccidioides brasiliensis in Saccharomyces cerevisiae

P1733Proprotein convertase subtilisin/kexin type 9 (PCSK9), platelet activation and risk of cardiovascular events in atrial fibrillation

P765Anti-proprotein convertase subtilisin-kexin type 9 monoclonal antibodies: effects on lipid profile and arterial stiffness

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice

Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

P635Plasma Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) level is associated with cardiovascular events: Findings from a community-based prospective study and a meta-analysis

P6230Measurement assay and inflammation influence the predictive role of levels of proprotein convertase subtilisin/kexin type 9 for cardiovascular events: a meta-analysis and a meta-regression analysis

5966Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and incident type 2 diabetes mellitus: a systematic review and meta-analysis with over 10,000 patients

 

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A family of subtilisin-like peptidases, of which furin is another example. All members are from eukaryotes although there are various kexin-like peptidases from prokaryotes. Kexin itself is a yeast serine peptidase of the S8 family (EC 3.4.21.61) that processes the precursors of α-factors and killer toxin; the mammalian kexin-like peptidases are involved in processing of various proproteins. Proprotein convertase-1 (PC1; proprotein convertase subtilisin/kexin-type 1, PCSK1; EC 3.4.21.93, 753 aa) and PC2 (EC 3.4.21.94, 638 aa) are neuroendocrine convertases that differentially cleave pro-opiomelanocortin and process proinsulin and proglucagon in pancreatic islets. PC4 (proprotein convertase subtilisin/kexin-type 4, PCSK4, 755 aa) is involved in processing pro-IGF2 (pro-*insulin-like growth factor II) to produce the intermediate IGF2 (1–102) that is further cleaved to the active form by another peptidase. Mutation in PCSK4 is associated with intrauterine growth restriction. PC5 (PCSK5, 913 aa) mediates post-translational endoproteolytic processing of several integrin α subunits. The gene encoding the proprotein convertase subtilisin/kexin type 9 (PCSK9, 692 aa) is linked to familial hypercholesterolemia and the product is involved in hepatocyte-specific low-density lipoprotein receptor degradation.

Subjects: Medicine and Health.


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