A family of adaptor proteins associated with focal adhesions and involved in activation of integrins by talin (inside-out signalling) and for the outside-in signalling through integrins that enables adhesion and spreading. Kindlin-1 (kindlerin, 677 aa) is localized in basal epidermal keratinocytes and defects are associated with Kindler's syndrome. Kindlin-2 (mitogen induced gene 1, MIG1, 680 aa, see migfilin) is an essential component of the intercalated discs of cardiac muscle and cell-matrix adhesion sites. Kindlin-3 (667 aa) is associated with activation of platelet integrins and deficiency is associated with severe bleeding.
Subjects: Medicine and Health.