Kirsten sarcoma virus

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A replication-defective murine retrovirus, generated by passaging a murine erythoblastosis virus in newborn rats. Source of the Ki-ras oncogene that encodes a GDP/GTP-binding protein (see ras). KRAS1 is a pseudogene but KRAS2 is mutated in 17–25% of all human tumours.

Subjects: Medicine and Health.

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