A subfamily of transcription factors that have three Krüppel-like zinc fingers. Tissue-specific forms include erythroid Krüppel-like factor (KLF1); gut-enriched Krüppel-like factor (GKLF; KLF4). KLF2 regulates T-cell quiescence and survival and is essential for T-cell trafficking; KLF5 is important in regulating myosin production in vascular smooth muscle; KLF6 is mutated in a subset of human prostate and gastric cancers; KLF7 is ubiquitious; KLF8 mediates cell cycle progression downstream of focal adhesion kinase (FAK) by upregulating cyclin D1. Mutations in KLF11 are associated with early-onset type 2 diabetes. KLF13 regulates RANTES genes; KLF15 is an inhibitor of cardiac hypertrophy; KLF16 regulates the expression of dopamine receptor genes.
Subjects: Medicine and Health.