Overview

Ku autoantigen


Show Summary Details

Quick Reference

A heterodimeric protein (732 aa and 609 aa) that has ATP-dependent DNA unwinding activity and binds DNA double-strand breaks facilitating repair by the nonhomologous end joining (NHEJ) pathway. See KARP-1. The subunits are autoantigens in systemic lupus erythematosus and thyroid lupus.

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.