Ku autoantigen

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A heterodimeric protein (732 aa and 609 aa) that has ATP-dependent DNA unwinding activity and binds DNA double-strand breaks facilitating repair by the nonhomologous end joining (NHEJ) pathway. See KARP-1. The subunits are autoantigens in systemic lupus erythematosus and thyroid lupus.

Subjects: Medicine and Health.

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