Overview

Kunitz domain


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Protein domain characteristic of inhibitors of the S1 serine peptidase family. Examples are aprotinin, trypstatin, a rat mast cell inhibitor of trypsin, and tissue factor pathway inhibitor (TFPI). Kunitz-type serine protease inhibitors SPINT1 (478 aa) and SPINT2 (252 aa) are specific inhibitors of the peptidase that activates hepatocyte growth factor.

Subjects: Medicine and Health.


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