Overview

lacticin


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A two-peptide lantibiotic produced by Lactococcus lactis in which both peptides, LtnA1 and LtnA2, must interact to produce antibiotic activity. LtnA1 interacts specifically with lipid II in the outer leaflet of the bacterial cytoplasmic membrane and then recruits LtnA2 to generate a three-component complex which inhibits cell-wall biosynthesis and forms a potassium-permeable pore.

Subjects: Medicine and Health.


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