Lanthionine-containing peptide antibiotics. Type A lantibiotics (e.g. nisin, subtilin, epidermin) are flexible, elongated, amphipathic molecules which act mainly by forming pores in the bacterial cytoplasmic membrane. Type B lantibiotics (e.g. ancovenin, mersacidin, actagardine, mutacin, and duramycin) have a rigid globular shape and inhibit particular enzymes by forming a complex with their membrane-bound substrates.
Subjects: Medicine and Health — Chemistry.