An adaptor protein (lysosome-associated apoptosis-inducing protein containing PH and FYVE domains, 279 aa) that recruits phosphorylated p53 to lysosomes. Overexpression of LAPF in L929 cells induces apoptosis and also increases cell sensitivity to TNFα-induced apoptosis. A member of the phafin family.
http://www.jbc.org/cgi/content/full/280/49/40985 Article on LAPF in the Journal of Biological Chemistry (2005).
Subjects: Medicine and Health.