A protein (La autoantigen, La ribonucleoprotein domain family 3, LARP3, 408 aa) that is involved in diverse aspects of RNA metabolism, including binding and protecting RNA that has been newly synthesized by polymerase III, stabilizing nascent pre-tRNAs from nuclease degradation, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. It is the nuclear autoantigen in patients suffering from Sjögren's syndrome, systemic lupus erythematosus, and neonatal lupus. La-related protein (LARP1) has an RNA-binding domain similar to that of La protein and a second conserved domain, the LARP1 domain, which also has RNA-binding ability. Other LARPs have been found; e.g. LARP7 is a negative transcriptional regulator of polymerase II genes.
Subjects: Medicine and Health.