Under the Revised European–American Lymphoma (REAL) classification schema, the non-Hodgkin's lymphomas are subdivided. Diffuse large cell lymphomas (DLCL) are mostly of B-cell origin and are the commonest of the non-Hodgkin's lymphomas; mutations in p53 are common. Less common is anaplastic large cell lymphoma (cutaneous CD30+ ALCL) which is clinically and pathologically heterogeneous but generally arises from T cells. In many cases there is up-regulation of a tyrosine kinase (anaplastic lymphoma kinase, ALK) due to a chromosomal translocation involving the nucleophosmin gene on chromosome 5.
Subjects: Medicine and Health.