Oncogenic viral proteins expressed in Epstein–Barr virus (EBV)-associated Hodgkin's lymphoma and nasopharyngeal carcinoma. They interact with various intracellular signalling systems to induce proliferation and metastasis. LMP-1 (BNFL1, 386 aa) is a member of the TNF-receptor family and interacts with tumour necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) but does not induce apoptosis, rather it up-regulates anti-apoptotic genes, including bcl-2. LMP2A signals through the src-kinase lyn and up-regulates the survivin gene through the NFκB pathway, making the cells resistant to apoptotic stimuli.
Subjects: Medicine and Health.