latent membrane proteins

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latent membrane proteins

Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGFα prior to neoplasia

Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein–Barr virus (EBV)-associated diseases

The Molecular Epidemiology and Evolution of Epstein-Barr Virus: Sequence Variation and Genetic Recombination in the Latent Membrane Protein-1 Gene

Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion

Epstein–Barr virus latent membrane protein-2A alters mitochondrial dynamics promoting cellular migration mediated by Notch signaling pathway

Detection of Epstein-Barr virus-encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients.

Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway

The 30-bp Deletion Variant of Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Prevails in Acute Infectious Mononucleosis

Sequence Variation of Latent Membrane Protein-1 of Epstein-Barr Virus Strains Associated with Hairy Leukoplakia

Induction of the Epstein-Barr Virus Latent Membrane Protein 2 Antigen-specific Cytotoxic T Lymphocytes Using Human Leukocyte Antigen Tetramer-based Artificial Antigen-presenting Cells

Restricted Low-Level Human Antibody Responses against Epstein-Barr Virus (EBV)—Encoded Latent Membrane Protein 1 in a Subgroup of Patients with EBV-Associated Diseases

The latent membrane protein 1 of Epstein–Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo

Nuclear epidermal growth factor receptor interacts with transcriptional intermediary factor 2 to activate cyclin D1 gene expression triggered by the oncoprotein latent membrane protein 1

Carboxy Terminal Variants of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 during Long-Term Human Immunodeficiency Virus Infection: Reliable Markers for Individual Strain Identification


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Oncogenic viral proteins expressed in Epstein–Barr virus (EBV)-associated Hodgkin's lymphoma and nasopharyngeal carcinoma. They interact with various intracellular signalling systems to induce proliferation and metastasis. LMP-1 (BNFL1, 386 aa) is a member of the TNF-receptor family and interacts with tumour necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) but does not induce apoptosis, rather it up-regulates anti-apoptotic genes, including bcl-2. LMP2A signals through the src-kinase lyn and up-regulates the survivin gene through the NFκB pathway, making the cells resistant to apoptotic stimuli.

Subjects: Medicine and Health.

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