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Chemokines (CCL3, ~92 aa) of the small chemokine (SCY) family that probably play an inhibitory role in haematopoiesis. LD78-α promotes migration of human peripheral T lymphocytes and enhances the adherence of monocytes to endothelial cells. LD78-β strongly down-regulates the expression of CCR5 in monocytes and macrophages and is a potent HIV-1 inhibitor (acting through CCR5), neutrophil activator (through CCR1), and eosinophil activator (through CCR1 and CCR3).

Subjects: Medicine and Health.

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