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LEFTY


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Genes involved in the determination of left–right asymmetry; LEFTY1 and -2 encode proteins (366 aa) of the TGFβ family which may antagonize nodal. In mice the equivalent genes are expressed only on the left-hand side of the embryo and mutations in LEFTY2 are associated with human L–R axis malformations.

Subjects: Medicine and Health.


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