Overview

leiomodin


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An actin-binding protein (572 aa) that is expressed in muscle, eye, and thryoid and is the autoantigen in some cases of Graves' disease where there is the complication of thyroid-associated ophthalmopathy. There are sequence similarities that suggest leiomodin, and tropmodulin may have evolved from a common ancestral gene. May nucleate sarcomere assembly in striated muscle.

Subjects: Medicine and Health.


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