Overview

leptin receptor


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'leptin receptor' can also refer to...

leptin receptor

Human Leptin and Leptin Receptor Deficiency

leptin receptor (OB-R protein)

leptin receptor (OB-R protein)

Leptin, Leptin Receptors, and the Control of Body Weight

Obesity induces functional astrocytic leptin receptors in hypothalamus

Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure

The Expression and Value of Leptin and Leptin Receptor in Human Esophageal Carcinoma

Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor

Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

The leptin receptor promoter controls expression of a second distinct protein

Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts

Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways

No evidence for mutations of the leptin or leptin receptor genes in women with polycystic ovary syndrome

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

Crucial Role of the Central Leptin Receptor in Murine Trypanosoma cruzi (Brazil Strain) Infection

Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication

Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth

 

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A protein containing 894 amino acids which appears to be a receptor for leptin, the product of the obesity gene, ob. The protein has the properties of a membrane-bound receptor. OB-R mRNAs occur in the hypothalamus, a region controlling energy balance, and other areas of the mouse brain. The OB-R protein is encoded by a gene on mouse chromosome 4, and the homologous human gene has also been identified. The fat cells of massively obese humans, who appear to carry ob + alleles, contain elevated amounts of leptin mRNA. Therefore, these individuals seem to lack OB-Rs. See Chronology, 1995, Tartaglia et al.; diabetes mellitus.

Subjects: Genetics and Genomics — Chemistry.


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