A protein containing 894 amino acids which appears to be a receptor for leptin, the product of the obesity gene, ob. The protein has the properties of a membrane-bound receptor. OB-R mRNAs occur in the hypothalamus, a region controlling energy balance, and other areas of the mouse brain. The OB-R protein is encoded by a gene on mouse chromosome 4, and the homologous human gene has also been identified. The fat cells of massively obese humans, who appear to carry ob + alleles, contain elevated amounts of leptin mRNA. Therefore, these individuals seem to lack OB-Rs. See Chronology, 1995, Tartaglia et al.; diabetes mellitus.
Subjects: Genetics and Genomics — Chemistry.