A cytokine (202 aa) that regulates growth and differentiation of primordial germ cells and embryonic stem cells but also has effects on peripheral neurons, osteoblasts, adipocytes, and various cells of the myeloid lineage. Can induce weight loss, behavioural disorders, and bone abnormalities in adults. Many of the effects of LIF in vitro can be mimicked by interleukin-6, oncostatin M, and ciliary neurotrophic factor, all of which interact indirectly with gp130, a shared tranducer subunit. Not to be confused with leucocyte inhibitory factor (leucocyte migration inhibitory factor), an operational definition of an activity rather than a distinct factor.
Subjects: Medicine and Health — Chemistry.