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A membrane-anchored protein (lymphocyte function-related antigen-3, CD58, 222 aa), expressed on cytolytic T cells, that is the ligand or counter-receptor for CD2, an adhesion mechanism distinct from the LFA-1/*ICAM-1 system. Both LFA-3 and CD2 are members of the immunoglobulin superfamily and are thought to have arisen by duplication of a common evolutionary precursor. Binding of erythrocyte LFA-3 to T-cell CD2 is the basis of E-rosetting.

Subjects: Medicine and Health.

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