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A cytoplasmic RNA helicase (678 aa) related to RIG-I and mda-5 but that functions as a negative regulator of RIG-I by blocking the dimerization of RIG-I and preventing the induction of interferon production. LGP2 apparently competes with the kinase IKKi (IKKε) for a common interaction site on MAVS.

Subjects: Medicine and Health.

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