LIM kinase

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A small subfamily with a unique combination of two LIM motifs and a C-terminal protein kinase domain. They are probably components of an intracellular signalling pathway and may be involved in brain development, regulate actin treadmilling by phosphorylating members of the ADF/cofilin family of proteins, and are themselves activated by PAK. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams' syndrome. LIMS1 (LIM and senescent cell antigen-like domains-1; particularly interesting new Cys-His protein, PINCH1; 314 aa) has five LIM domains and is an obligate partner of integrin-linked kinase both of which are necessary for proper control of cell shape change, motility, and survival.

Subjects: Medicine and Health.

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