LIM domain

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Highly conserved double zinc finger motif that will bind to a second LIM domain to mediate protein–protein interactions. Found in many proteins involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Named after the first three members: Lin-11 (required for asymmetric division of blast cells in Caenorhabditis elegans), IsI-1 (mammalian insulin-gene binding enhancer protein), and mec-3 (required for differentiation of a set of sensory neurons in C. elegans).

Subjects: Medicine and Health.

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